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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: SLC12A5 All Species: 13.64
Human Site: T899 Identified Species: 27.27
UniProt: Q9H2X9 Number Species: 11
    Phosphosite Substitution
    Charge Score: -0.09
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens Q9H2X9 NP_001128243.1 1139 126184 T899 I Q M K K D L T T F L Y H L R
Chimpanzee Pan troglodytes XP_001173480 1150 127612 N910 V E Q F S E G N I D V W W I V
Rhesus Macaque Macaca mulatta XP_001104798 1116 123517 T876 I Q M K K D L T T F L Y H L R
Dog Lupus familis XP_543029 1042 114973 F814 V T K N V S M F P G N P E R F
Cat Felis silvestris
Mouse Mus musculus Q91V14 1138 126252 T899 I Q M K K D L T T F L Y H L R
Rat Rattus norvegicus Q63633 1139 126228 T899 I Q M K K D L T T F L Y H L R
Wallaby Macropus eugenll
Platypus Ornith. anatinus XP_001506148 1141 126778 Q913 I Q M K K D L Q M F L Y H L R
Chicken Gallus gallus NP_001006371 1125 125222 Q893 I Q M K K D L Q M F L Y H L R
Frog Xenopus laevis Q0VGW6 899 98326 H671 D A T S L Q A H F P P A R D P
Zebra Danio Brachydanio rerio A2BFP5 899 98457 L671 F G V D L P S L Q A H F P P V
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster
Honey Bee Apis mellifera
Nematode Worm Caenorhab. elegans Q09573 1020 112280 L792 Q D G G I L M L I A Y L L R Q
Sea Urchin Strong. purpuratus
Poplar Tree Populus trichocarpa
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana
Baker's Yeast Sacchar. cerevisiae P38329 1120 123980 K886 K Q F T Q S R K Y T S G V Q K
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 69.6 96.1 88 N.A. 98.2 98.2 N.A. 72.1 73 24.6 25.2 N.A. N.A. N.A. 35.9 N.A.
Protein Similarity: 100 81 97 89.1 N.A. 98.6 98.8 N.A. 82.9 83.9 42.7 43.1 N.A. N.A. N.A. 54.8 N.A.
P-Site Identity: 100 0 100 0 N.A. 100 100 N.A. 86.6 86.6 0 0 N.A. N.A. N.A. 0 N.A.
P-Site Similarity: 100 40 100 13.3 N.A. 100 100 N.A. 86.6 86.6 0 13.3 N.A. N.A. N.A. 13.3 N.A.
Percent
Protein Identity: N.A. N.A. N.A. N.A. 20.3 N.A.
Protein Similarity: N.A. N.A. N.A. N.A. 38.1 N.A.
P-Site Identity: N.A. N.A. N.A. N.A. 6.6 N.A.
P-Site Similarity: N.A. N.A. N.A. N.A. 20 N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 0 9 0 0 0 0 9 0 0 17 0 9 0 0 0 % A
% Cys: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % C
% Asp: 9 9 0 9 0 50 0 0 0 9 0 0 0 9 0 % D
% Glu: 0 9 0 0 0 9 0 0 0 0 0 0 9 0 0 % E
% Phe: 9 0 9 9 0 0 0 9 9 50 0 9 0 0 9 % F
% Gly: 0 9 9 9 0 0 9 0 0 9 0 9 0 0 0 % G
% His: 0 0 0 0 0 0 0 9 0 0 9 0 50 0 0 % H
% Ile: 50 0 0 0 9 0 0 0 17 0 0 0 0 9 0 % I
% Lys: 9 0 9 50 50 0 0 9 0 0 0 0 0 0 9 % K
% Leu: 0 0 0 0 17 9 50 17 0 0 50 9 9 50 0 % L
% Met: 0 0 50 0 0 0 17 0 17 0 0 0 0 0 0 % M
% Asn: 0 0 0 9 0 0 0 9 0 0 9 0 0 0 0 % N
% Pro: 0 0 0 0 0 9 0 0 9 9 9 9 9 9 9 % P
% Gln: 9 59 9 0 9 9 0 17 9 0 0 0 0 9 9 % Q
% Arg: 0 0 0 0 0 0 9 0 0 0 0 0 9 17 50 % R
% Ser: 0 0 0 9 9 17 9 0 0 0 9 0 0 0 0 % S
% Thr: 0 9 9 9 0 0 0 34 34 9 0 0 0 0 0 % T
% Val: 17 0 9 0 9 0 0 0 0 0 9 0 9 0 17 % V
% Trp: 0 0 0 0 0 0 0 0 0 0 0 9 9 0 0 % W
% Tyr: 0 0 0 0 0 0 0 0 9 0 9 50 0 0 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _